By A. F. List, C. M. Spier, W. S. Dalton (auth.), Prof. Dr. W. Hiddemann, Prof. Dr. T. Büchner, Priv. Doz. Dr. B. Wörmann, Prof. Dr. W. Plunkett, Prof. Dr. M. Keating, Prof. Dr. M. Andreeff (eds.)
This is often the 3rd quantity during this sequence on tools of treating acute leukemia. a number of drug resistance is mentioned, in addition to using human granulocyte-macrophage CSF, the position of stem phone issue, and uncomplicated facets of mobile biology and pharmakokinetics. there's additionally a finished part facing relapse remedy and postremission remedy. The ebook hence presents the clinician with guidance to be used in daily perform.
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Beck WT (1987) The cell biology of multiple drug resistance. Biochem Pharmacol 36: 2879-2887 6. Endicott JA, Ling V (1989) The biochemistry of P-glycoprotein-mediated multidrug resistance. Annu Rev Biochem 58: 1137-1171 8 7. Pastan I, Gottesman M (1987) Multiple-drug resistance in human cancer. N Engl J Med 316: 1388-1393 8. Dalton WS, Grogan TM, Rybski JA, et al. (1989) Immunohistochemical detection and quantitation of P-glycoprotein in multiple drug-resistant human myeloma cells: association with level of drug resistance and drug accumulation.
Thus both intrinsic resistance to high pulse doses of MTX [23, 24] as well as acquired resistance may result from defective polyglutamate formation [25-27]. We recently examined the possibility that the dose schedule of MTX employed may influence the type of resistance obtained. M), and following regrowth, cells were repeatedly exposed to this drug in this same schedule. After 6-7 cycles of exposure, cell growth was no longer significantly affected by this dose of drug. The mechanism of resistance found in these cell lines (CCRF-CEM R 3/7 and CCRF-CEM R 30/6) was impaired polyglutamylation [27].
Biochem Pharmacol 36: 2879-2887 6. Endicott JA, Ling V (1989) The biochemistry of P-glycoprotein-mediated multidrug resistance. Annu Rev Biochem 58: 1137-1171 8 7. Pastan I, Gottesman M (1987) Multiple-drug resistance in human cancer. N Engl J Med 316: 1388-1393 8. Dalton WS, Grogan TM, Rybski JA, et al. (1989) Immunohistochemical detection and quantitation of P-glycoprotein in multiple drug-resistant human myeloma cells: association with level of drug resistance and drug accumulation. Blood 73: 747-752 9.
