By Leo Sachs (auth.), Prof. Dr. W. Hiddemann, Priv.-Doz. Dr. W. Plunkett, Prof. Dr. T. Büchner, Prof. Dr. J. Ritter, B. Wörmann M.D., Ph.D., M. J. Keating M.D., B.S., Prof. Dr. U. Creutzig (eds.)

This quantity, the 5th in a chain on acute leukemias, focuses fairly on fresh uncomplicated study effects and novel healing methods to the illness. facets of leukemia cellphone biology, together with differentiation, the mechanisms of drug resistance, the pharmacology of cytostatic brokers and the result of scientific trials in relapsed and refractory affliction are lined through awesome foreign specialists within the respective fields. destiny advancements together with new brokers and new healing procedures comparable to unrelated bone marrow transplantation, immunotargeting and gene remedy entire a state of the art summery of present wisdom in experimental leukemia therapy.

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Extra resources for Acute Leukemias V: Experimental Approaches and Management of Refractory Disease

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Because the AUC is a sum of accumulation and elimination rates of ara-CTP, we determined whether the increased intracellular exposure to ara-CTP resulted from a decrease in the rate of ara-CTP elimination by comparing the half-time (e I2 ) of ara-CTP retention before and after fludarabine infusion (Table 2). 0 h among the 5 patients during the first Table 2. 001 230±62 38 ±16 *ara-C infusion 4 h after fludarabine infusion #mean fludarabine+ara-C values mean ara-C alone values Intracellular levels of ara-CTP were determined in circulating AML blasts by highpressure liquid chromatography.

Res. , 156: 1265-1270. 51. Sachs L. 1982. Normal development programmes in myeloid leukaemia. Regulatory proteins in the control of growth and differentiation. Cancer Surveys 1: 321-342. 52. Degos L. 1992. AIl-trans-retinoic aeid treatment and retinoic acid receptor alpha gene rearrangement in acute promyelocytic leukemia: a model for differentiation therapy. Int. J. Cell Cloning 10: 63-69. 53. R. 1990. Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis. Nature 343: 76-79.

10. , Sachs 1. 1966. The induction of clones of normal "mast" cells by a substance from conditioned medium. Exp. Cell Res. 43: 553-563. 11. , Resnitzky P. 1970. In vitro induction of granulocyte differentiation in hematopoietic cells from leukemic and nonleukemic patients. Proc. Nat!. Acad. Sci. USA 67: 1542-1549· 12. A. 1970. Human bone marrow growth in agar gel. J. Cell Physiol. 76: 77-84. 13. M. 1971. Induction of colonies of hemoglobin-synthesizing cells by erythropoietin in vitro. Proc. Nat!.

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