By Steven Akman, Regen Drouin, Gerald Holmquist (auth.), Miral Dizdaroglu, Ali Esat Karakaya (eds.)
Damage to DNA by way of either exogenous and endogenous assets is more and more considered as hugely very important within the initiation and development of melanoma and within the occurance of different pathological occasions. DNA harm because of reactive oxygen-derived species, also referred to as oxidative DNA harm, is such a lot the widespread style encountered via cardio cells. Mechanistic stories of carcinogenesis point out a big function of this kind of harm to DNA. there's additionally robust facts to help the position of oxidative DNA harm within the getting older method. DNA harm is antagonistic in vivo via fix platforms. If now not repaired, DNA harm could lead to dangerous organic outcomes. hence, the fix of DNA harm is thought of as one of many crucial occasions in all existence types. in recent times the sphere of DNA fix has flourished as a result of new findings on DNA fix mechanisms and the molecular foundation of melanoma. a close wisdom of mechanisms of DNA harm and service, and the way person fix enzymes functionality could lead on to manipulation of DNA fix in cells and finally to a rise of the resistence of human cells to DNA-damaging brokers. This quantity covers the latest devlopments during this learn box and comprises contributions from scientists operating within the fields of biochemistry, molecular biology, enzymology, biomedical technological know-how, and radiation biology.
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Additional info for Advances in DNA Damage and Repair: Oxygen Radical Effects, Cellular Protection, and Biological Consequences
This has not yet been accomplished. There are many types of oxidative base modifications in DNA that are seen in human cells, and the accumulation of anyone single lesion could possibly be a very important factor in the development of the molecular phenotype. In support of our results, a previous study found that expression of a metalloproteinase was reduced to 50% in CS cells (Millis et al (92», and very recently it was reported that the CSB protein affects transcription as a purified component in vitro (Selby et al (97a».
For the food matrix, the emphasis is on minimizing oxidation to the lipid component of the food. Different factors have to be considered in vivo. Iron ions catalytic for free radical reactions are safely sequestered in the human body. g. in advanced atherosclerotic lesions (Smith et al 1992). Ehrenwald et al (1994) have claimed that caeruloplasmin containing one redox active copper per protein molecule can oxidize LDL in the presence of cells. Indeed, increased serum copper levels are associated with accelerated progression of carotid atherosclerosis in humans.
Advances in DNA Damage and Repair, edited by Dizdaroglu and Karakaya. Kluwer Academic / Plenum Publishers, New York. 1999. 35 36 S. Boiteux and J. P. Radicella 2. INTRODUCTION Considerable interest has arisen in recent years in the study of the biological consequences and the repair of oxidative damage to DNA. , 1994). In the case of cancer, oxidative damage to DNA is thought to cause mutations that activate oncogenes or inactivate tumor suppressor genes. Oxidative DNA damage is the result of the reaction between DNA and reactive oxygen species (ROS) which are formed as byproducts of normal metabolism and during exposure to physical and chemical environmental agents.