By Qing-Ping Zeng
This ebook discusses either the useful and damaging elements of NO in biology and medication, and in addition introduces the rising discovery of artemisinin in antitumor, antibacterial an infection, anti-inflammation, and antiaging contexts. In 1992 nitric oxide (NO) was once voted “Molecule of the yr” through technology journal, and the invention of its physiological roles has resulted in Nobel Prize-winning paintings in neuroscience, body structure and immunology. The ebook explains why we must always retain a steady-state NO point that's derived from neuronal or epithelial NO synthase, and steer clear of the super excessive NO point because of inducible NO synthase. The booklet deals a beneficial source for clinical chemists, clinicians, biologists and all these attracted to wellbeing and fitness and disease.
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Extra info for Artemisinin and Nitric Oxide: Mechanisms and Implications in Disease and Health
2 Production of ART in Transgenic Plants and Engineered Microbes Although the biosynthesis of ART is unique in A. , its “upstream” biosynthetic pathway is ubiquitous among eukaryotes including microorganisms. Therefore, it is possible to re-establish a “downstream” ART biosynthetic pathway in yeast (Zeng et al. 2008a). In the past decade, ART biosynthetic genes were successfully cloned and introduced into yeast, resulting in the production of ART precursors including artemisinic acid and dihydroartemisinic acid (Zeng et al.
2003). The cytotoxicity of ART to tumor cells was first evaluated by Woerdenbag et al. (1993). Later, ART’s cytotoxicity was shown to be endoperoxide-dependent (Beekman et al. 1998). -P. 1007/978-3-662-47688-8_3 29 30 3 ART for Antitumor proposed (Kwok and Richardson 2002). Tumor cells in exposure to ART were found to exhibit a correlation of mitigated proliferation with repressed angiogenesis (Krishna et al. 2008). Recent evidence suggests that ART may share a common feature with the heme-interacting compound coralyne because both exert the cytotoxicity in a heme-dependent manner (Zhang and Gerhard 2009).
In the studies with infected mice, detection of heme-drug adducts (as glucuronyl-conjugated derivatives) indicated that ART-mediated alkylation might be a key factor that exerts antimalarial activity in vivo. Because the progression of malarial infection ultimately leads to hematin deposition in the liver and spleen of infected mice, it is of course unable to rule out a possibility of the heme-drug adducts being derived from the interactions of parasites with mouse organs (O’Neill et al. 2010).