By WHO Technical Report Series

This record of a WHO specialist Committee reports present wisdom of Chagas sickness and its pathogenesis discusses the causative parasite the triatomine vectors and the typical reservoirs of an infection and considers the epidemiology and occurrence developments of the illness. Prevention and regulate recommendations are defined as are a few of the formal projects for interruption of ailment transmission. The document concludes by means of deciding upon priorities for examine and delivering information for the making plans implementation and strengthening of nationwide regulate courses.

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Extra info for Control of Chagas Disease: 2nd Report of the WHO Expert Committee on Chagas Disease (Technical Report Series)

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In extremely severe acute cases with a high degree of myocardiopathy and for meningoencephalitis, radical treatment, such as the combination of corticoid drugs with specific parasitological treatment, could be attempted. Etiological treatment The acute phase of Chagas disease is characterized by the presence of parasites that are easily demonstrable in peripheral blood. Etiological treatment clears parasites from the peripheral blood and shortens the duration of the symptoms, including those of acute myocarditis and meningoencephalitis when present.

Domiciliary and peridomestic habitats may create favourable microhabitats and provide protection from predators. Other factors include the abundant blood supply offered by humans as well as the protection found by the vector on the surfaces of mud walls. 50 Domiciliary habitats related to house construction include cracks and crevices in mud or concrete walls, the junctions between adobe or concrete bricks, spaces between pieces of wood or cane, roofs made of palm trees, and earthen floors. Other factors that favour bug infestation include the storage of harvested crops in the house, collections of adobe blocks in indoor passages and corridors, and piles of sticks in the house.

G. multilocus enzyme electrophoresis (MLEE), DNA methods, or morphometrics, can help in elucidating the genetic and phenotypic changes associated with domiciliation. These techniques have shown that the process is usually associated with major migrations, the reduction of genetic repertoire, and increasing developmental instability, making the insect a more efficient vector as well as a more vulnerable target of control measures. Since only some of the sylvatic genotypes may be successful in establishing durable domestic colonies, some restriction of genetic variability is assumed to occur during the early stages of the domiciliation process.

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