By Charles Darwin

The Formation of Vegetable mold during the motion of Worms with Observations on their conduct. With an advent via sir Albert Howard . octavo pp. 154 Rilegato tela, sovracoperta (cloth, airborne dirt and dust jacket) Ottimo (Fine)

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C. 3 mg CB-154/rat oenanthate, being a synthetic nortestosterone progestagen with inherent oestrogenic activity, was much more effective in stimulation of mammary growth in spite of a lesser effect on PRL level. This marked stimulatory effect of norethisterone oenanthate on the mammary gland could only be partly counteracted by CB-154. This might suggest that CB-154 antagonized norethisterone oenanthate's stimulatory action on PRL secretion, which is involved in mammary growth. However, a direct effect of norethisterone oenanthate on the mammary gland seems to be of great importance (see Fig.

85-92. Berlin, Heidelberg, New York: Springer 1979 Goluboff, L. : Effect of pregnancy on the somatotroph and the prolactin cells of the human adenohypophysis. J. Clin. Endocrino!. Metab. , El Etreby, M. : The role of the anterior pituitary gland in progestagen-induced proliferative mammary gland changes in the beagle. Arzneimittel-Forsch. , El Etreby, M. : Effect of prolactin inhibitory agents on the ectopic anterior pituitary and the mammary gland in rats. Acta Endocrino!. , Koch, U. : Hyperprolactinemia induced by cyproterone acetate in human subjects.

1972; EI Etreby and Giinzel, 1973, 1974; Saeger, 1977). In a recent study of 191 women with secondary amenorrhoea, the cause was found to be pituitary tumours in 26% of 69 former users of oral contra- • 32 30 ,\ 25 I 20 15 , f. tt-tf\ fo4 Ii . ,. ,1':. r I" in I, I '\ ,"" - L "I ,I ~ II 10 i ,. 5 . • Nt, 90' 0' 90' 90' 0' 90' 0' 0' 90' 0' Pretreat- 4th week 5th week 6th week 7th week ment under CPA (SO mg/day p,o,) treatment period 1 ~ 0' 90' min Posttreatment period Fig. 6. o. Eight samples were taken every 15 minutes over 2 hours, one week before and one week after treatment, as well as at the end of the 4th, 5th, 6th, and 7th weeks of treatment.

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